Ye-Guang Chen, Ph.D

Professor, School of Basic Medicine, Nanchang University

Professor, School of Life Sciences, Tsinghua University

2022-now, Professor, Nanchang University, Nanchang

2002-now, Professor, Tsinghua University, Beijing

2000-2002, Assistant Professor, Division of Biomedical Sciences, University of California, Riverside

1996-2000, Postdoc fellow, HHMI/Memorial Sloan-Kettering Cancer Center, New York

1991-1996, PhD, Albert Einstein College of Medicine, New York

1988-1990, MSc, Department of Biological Sciences, Fordham University

1983-1986, MSc, Department of Biology, Jiangxi University

1979-1983, BSc, Department of Biology, Jiangxi University

2023, National Excellence Award

2020, Member, The World Academy of Sciences

2017, Member, Chinese Academy of Sciences

2011, The CST Achievement Award, the Chinese Society for Cell Biology

2008, Ho Leung Ho Lee Foundation Prize for Scientific and Technological Progress

2006, Achievement Award of Sciences and Technology for Young Chinese

2002, Cheung Kong Scholarship

2002, Recipient, National Science Foundation for Outstanding Young Scientist of China

2002, The Li Foundation Heritage Prize for “Excellence in Creativity”, New York

Using multiple techniques of biochemistry, molecular biology, cell biology and bioinformatics in combination with organoid culture and mouse models, we investigate the self-renewal and differentiation mechanisms of adult stem cells of intestine and stomach, and explore the pathogenic mechanisms of related diseases, as well as drug discovery. We also explore how TGF-beta and Wnt signaling are regulated, aiming to understand their roles in stem cell biology, tissue homeostasis and related diseases.

2023-now, President, The Asian-Pacific Organization for Cell Biology

2023-now, Vice-Presidents, International Federation for Cell Biology

2019-now, Editor-in-Chief，Cell Regeneration

2015-2023, President, The Chinese Society of Cell Biology

1. Liu LS, Wang YL, Yu SC, Liu HD, Li YH, Hua S, Chen YG#. (2023) TGF-β promotes inflammation and tumorigenesis in Smad4-deficient intestinal epithelium in a YAP-dependent manner, Advanced Science, in press.

2. Liu Y, Huang MM, Wang XD, Liu ZN, Li SQ, Chen YG#. (2023) Segregation of the stemness program from the proliferation program in intestinal stem cells, Stem Cell Reports, S2213-6711(23)00095-4.

3. Kang KX, Shi QN, Wang X, Chen YG#. (2022) Dishevelled phase separation promotes Wnt signalosome assembly and destruction complex disassembly. Journal of Cell Biology, 221(12): e202205069.

4. Zhao LZ, Song WL, Chen YG#. (2022) Mesenchymal-epithelial interaction regulates gastrointestinal tract development in mouse embryos. Cell Reports, 40(2):111053.

5. Nong JX, Kang KX, Shi QN, Zhu XC, Tao QH, Chen YG#. (2021) Phase separation of Axin organizes the β-catenin destruction complex. Journal of Cell Biology, 220(4): e202012112.

6. Wang T, Zhang N, Fan SP, Zhao LZ, Song WL, Gong YH, Shen Q, Zhang C, Ren P, Lin CT, Fu W, Gao G, Ma SH#, Bi YH#, Chen YG#. (2021) Establishment of human distal lung organoids for SARS-CoV-2 infection. Cell Discovery, 7(1):108.

7. Wang YL, Song WL, Wang JL, Wang T, Xiong XC, Qi Z, Fu W#, Yang XR#, Chen YG#. (2020) Single-cell transcriptome analysis reveals differential nutrient absorption functions in human intestine. Journal of Experimental Medicine, 217(2). pii: e20191130.

8. Liao HW, Li X, Zhao LZ, Wang YL, Wang XD, Wu Y, Zhou X, Fu W, Liu L, Hu HG#, Chen YG#. (2020) A PROTAC peptide induces durable β-catenin degradation and suppresses Wnt-dependent intestinal cancer. Cell Discovery, 6(35):1.

9. Huang F, Shi Q, Li Y, Xu L, Xu C, Chen F, Wang H, Liao H, Chang Z, Liu F, Zhang XH, Feng XH, Han JJ, Luo S, Chen YG#. (2018) HER2/EGFR-AKT signaling switches TGF-β from inhibiting cell proliferation to promoting cell migration in breast cancer. Cancer Research, 78(21):6073.

10. Qi Z, Li Y, Zhao B, Xu C, Liu Y, Li H, Zhang B, Wang X, Yang X, Xie W, Li B, Han J, Chen YG#. (2017) BMP restricts stemness of intestinal Lgr5+ stem cells by directly suppressing their signature genes. Nature Communications, 8:13824.

11. Zhao B, Qi Z, Li Y, Wang C, Fu W, Chen YG#. (2015) The non-muscle-myosin-II heavy chain Myh9 mediates colitis-induced epithelium injury by restricting Lgr5+ stem cells. Nature Communications, 6:7166.

12. Zuo W, Huang F, Chiang YJ, Li M, Du J, Ding Y, Zhang T, Lee HW, Jeong LS, Chen Y, Deng H, Feng XH, Luo S, Gao C, Chen YG#. (2013) c-Cbl-mediated neddylation antagonizes ubiquitination and degradation of the TGF-β type II receptor. Molecular Cell, 49(3):499.

13. Li Z, Fei T, Zhang J, Zhu G, Wang L, Lu D, Chi X, Teng Y, Hou N, Yang X, Zhang H, Han JD, Chen YG#. (2012) BMP4 signaling acts via Dual Specificity Phosphatase 9 to control ERK activity in mouse embryonic stem cells. Cell Stem Cell, 10:171-182.

14. Gao C, Cao W, Bao W, Zuo W, Xie G, Cai T, Fu W, Zhang J, Wu W, Zhang X, Chen YG#. (2010) Autophagy negatively regulates Wnt signaling by promoting Dishevelled degradation. Nature Cell Biology, 12:781.