Jianbin Wang Lab

Principle Investigator

Prof. Jianbin Wang，supervisor of Ph.D. student

Dr. Jianbin Wang is currently a Professor of oncology, Director of Institute of Biomedical Sciences at Nanchang University. He got a National award for Baiqianwan Talent Program. He is a panel-review member for National Science Foundation of China (NSFC) and the reviewer for multiple scientific Journals; such as Journal of Biological Chemistry, Molecular Carcinogenesis, Cancer Report，and Comparative Biochemistry and Physiology.

He got his Ph.D. in the Department of Biological Science at the Chinese University of Hong Kong in 1995. Then he worked as a Research Associate in the Department of Molecular Medicine at Cornell University. He came back to China and worked as a faculty at Nanchang University in 2011.

Research Interest

The research efforts of Jianbin Wang’s laboratory have mainly focused on cancer metabolism including glutamine metabolism, serine metabolism, ketone body metabolism, glycolysis and anti-cancer drug selection. He has published more than 40 peer-reviewed papers, including Cancer Cell paper (Cover) and, Nature Cell Biology paper, Cell Research paper and Autophagy paper and so on.

Lab member

Dr. Tianyu Han，Associate Research Fellow

Associate Researcher of First Affiliated Hospital of Nanchang University/ Jiangxi Institute of Respiratory Disease. Jiangxi Province's "Thousand Talents Plan" Technology Innovation High end Talents, Academic and technical leaders in major disciplines in Jiangxi Province, Winner of Jiangxi Outstanding Youth Fund. His research interest focus on tumor metabolism and autophagy, and has published many papers in authoritative journals such as Cell Research, Autophagy, Cell Death & Disease. Part of the research achievements won the Second Prize in Natural Science in Jiangxi Province. He has presided over the General Program and Youth Program of the National Natural Science Foundation of China.

Dr. Yange Liu, Lecturer

Dr. Yange Liu graduated from Jilin University with a PHD in 2019. As the first author (including co-first author), she has published 7 papers and obtained 5 national patents. In 2019, she joined Professor Jianbin Wang's team in the Institute of Biomedical Sciences, Nanchang University. Her researches mainly focus on the separation and purification of natural products, identification of new drug targets, and exploration of their mechanisms of action.

Selected Publications

1. Jian-Bin Wang, Jon W Erickson, Reina Fuji, Sekar Ramachandran, Ping Gao, Ramani Dinavahi, Kristin F Wilson, Andre L B Ambrosio, Sandra M G Dias, Chi V Dang, Richard A Cerione. Targeting mitochondrial glutaminase activity inhibits oncogenic transformation. Cancer Cell (2010) 18: 207-219（封面文章） (影响因子: 38.58)

* 国际肿瘤专家对此文章进行了专门评论（Preview）

Preview：Lu W, Pelicano H, Huang P. Cancer metabolism: is glutamine sweeter than glucose? Cancer Cell. 2010 Sep 14; 18(3):199-200.

2. Tianyu Han, Weihua Zhan, Mingxi Gan, Fanrong Liu, Bentong Yu, Y. Eugene Chin & Jian-Bin Wang*. Phosphorylation of glutaminase by PKCε is essential for its enzymatic activity and critically contributes to tumorigenesis. Cell Research (2018) 28: 655–669. (影响因子: 46.37)

3. Tianyu Han, Meng Guo, Mingxi Gan, Bentong Yu, Xiaoli Tian & Jian-Bin Wang*. TRIM59 regulates autophagy through modulating both the transcription and the ubiquitination of BECN1. Autophagy (2018) 14: 2035–2048. (影响因子: 16.016)

4. Tianyu Han, Pengcheng Wang, Yanan Wang, Wenze Xun, Jiapeng Lei, Tao Wang, Zhuo Lu, Mingxi Gan, Wei Zhang, Bentong Yu & Jian-Bin Wang*. FAIM regulates autophagy through glutaminolysis in lung adenocarcinoma. Autophagy (2021) 31: 1-17. (影响因子: 16.016)

5. Tao Wang, Zhuo Lu, Tianyu Han, Yanan Wang, Mingxi Gan, Jian-Bin Wang*, Deacetylation of glutaminase by HDAC4 contributes to lung cancer tumorigenesis. International Journal of Biological Sciences (2022) 18：4452-4465. (影响因子: 10.75)

6. Feifei Zhou, Wenqian Ai, Yixing Zhang , Qifan Hu , Mingxi Gan , Jian-Bin Wang* and Tianyu Han. ARHGEF3 regulates the stability of ACLY to promote the proliferation of lung cancer. (2022) Cell Death & Disease 13:870; https://doi.org/10.1038 (影响因子: 9.68)

7. Yanan Wang, Jiapeng Lei, Song Zhang, Xiaomei Wang, Yufeng Liu, Jiangbo Jin, Mingxi Gan, Yi Yuan, Longhua Sun, Tianyu Han, and Jian-Bin Wang*, 4EBP1 Senses Extracellular Glucose Deprivation and Initiates Cell Death Signaling in Lung Cancer. (2022) Cell Death & Disease. 13（12） (影响因子: 9.68)

8. Yiming He, Mingxi Gan, Yanan Wang, Tong Huang, Jianbin Wang*, Tianyu Han*, Bentong Yu*. EGFR-ERK induced activation of GRHL1 promotes cell cycle progression by up-regulating cell cycle related genes in lung cancer. Cell Death & Disease. (2021) Apr 30;12(5):430. (影响因子: 9.68)

9. Zhuo Lu, Tianyu Han, Tao Wang, Mingxi Gan, Caifeng Xie, Bentong Yu, Jian-Bin Wang*. OXCT1 regulates NF-κB signaling pathway through β-hydroxybutyrate mediated ketone body homeostasis. Genes & Diseases, https://doi.org/10.1016/j.gendis.2022.04.020 (影响因子: 7.24)

10. Feifei Zhou1,2, Yufeng Liu1 , Wenqian Ai1 , Yanan Wang2 , Mingxi Gan1 , Qingkun Jiang3 , Tianyu Han and Jian‑Bin Wang1* GNIP1 functions both as a scaffold protein and an E3 ubiquitin ligase to regulate autophagy in lung cancer. Cell Communication and Signaling (2022) 20:133; https://doi.org/10.1186 (影响因子: 7.52)

11. Jian-Bin Wang, Robert Sonn, Yemmsrach K Tekletsadik, Daniel Samorodnitsky, Mahasin A Osman. IQGAP1 regulates cell proliferation through a novel Cdc42-mTOR pathway. Journal of Cell Science (2009) 122: 2024-33 (Highlighted editorially paper). (影响因子: 6.3)

12. Jian-Bin Wang, Wen Jin Wu, Richard A Cerione. Cdc42 and Ras cooperate to mediatedcellular transformation by Intersectin-L. Journal of Biological Chemistry (2005) 280: 22883-22891. (影响因子: 5.3)

13. Qiyu Feng, Dan Baird, Xu Peng, Jian-Bin Wang, Thi Ly, Jun-Lin Guan, Richard A Cerione Cool-1 functions as an essential regulatory node for EGF receptor- and Src- mediated cell growth. Nature Cell Biology (2006) 8: 945-956. (IF: 19.6)

14. Thi K Ly, Jian-Bin Wang, Ryan Pereira, Katherine S Rojas, Xu Peng, Qiyu Feng, Richard A Cerione, Kristin F Wilson Activation of the Ran GTPase is subject to growth factor regulation and give rise to cellular transformation. Journal of Biological Chemistry (2010) 285: 5815-26. (IF: 5.3)

15. Nancy Fidyk, Jian-Bin Wang, Richard A Cerione. Influencing cellular transformation by modulating the rates of GTP hydrolysis by Cdc42. Biochemistry (2006) 45: 7750-7762. (IF: 3.2)

16. Weihua Zhan, Wenjuan Wang, Tianyu Han, Caifeng Xie, Tingting Zhang, Mingxi Gan, Jian-Bin Wang*. COMMD9 promotes TFDP1/E2F1 transcriptional activity via interaction with TFDP1 in non-small cell lung cancer. Cellular Signaling (2017) 30: 59-66. (IF: 4.3)

Grants Approved

1. Key project of National Natural Science Foundation of China, The function and mechanism of the post-translational modification of rate-limiting enzyme SHMT2 of serine metabolism in regulating tumor metabolic reprogramming (82030086, 2021.01-2025.12）

2. Mian Shang project （面上项目）of National Natural Science Foundation of China, Studies on the function and molecular mechanism of OXCT1 regulating NF-κB in lung cancer (81874043，2019.01-2022.12)

3. Mian Shang project （面上项目）of National Natural Science Foundation of China, Studies on the function and molecular mechanism of glutaminase regulated by deubiquitylase USP14 in non-small cell lung cancer (81672298，2017.01-2020.12)

4. Mian Shang project （面上项目）of National Natural Science Foundation of China, Studies on the function and molecular mechanism of glutaminase regulated by NF-κB in breast cancer (81372823，2014.01-2017.12)

5. Di Qu project (地区项目）of National Natural Science Foundation of China, Studies on the molecular mechanism of EGFR regulated by glutaminase in breast cancer (31360282，2014.01-2017.12)

E-mail：jianbinwang@ncu.edu.cn

Office：Room 517, the fourth experimental building of Medical College of Nanchang University, No. 1299, Xuefu Avenue, Honggutan District, Nanchang City.

Phone：0791-83968264